Iowa State vs Lipscomb Odds, Opening Spread, Predictions for 2025 NCAA Tournament

Iowa State vs Lipscomb Odds, Opening Spread, Predictions for 2025 NCAA Tournament article feature image
Credit:

Guard Curtis Jones #5 of the Iowa State Cyclones. (Photo by Bruce Yeung/Getty Images)

Iowa State vs Lipscomb Odds

Iowa State Logo
Friday, March 21
1:30 p.m. ET
TNT
Lipscomb Logo
Iowa State Odds
SpreadTotalMoneyline
-14.5
-110
142.5
-110o / -110u
-950
Lipscomb Odds
SpreadTotalMoneyline
+14.5
-110
142.5
-110o / -110u
+625
Odds via DraftKings . Get up-to-the-minute NCAAB odds here.
DraftKings  Logo

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The 2025 NCAA Tournament field has been announced, and the Iowa State Cyclones will take on the Lipscomb Bison in Round 1 of the East region. Here's everything you need to know about Iowa State vs Lipscomb odds, spread, and more.

Iowa State opened as a 14.5-point favorite over Lipscomb in the first round of the NCAA Tournament. The total is set at over/under 142.5 points scored by both teams combined.

Find out how No. 3-seeded Iowa State and No. 14-seeded Lipscomb match up ahead of their opening round matchup.


Iowa State vs Lipscomb Analysis

Iowa State is a hell of a team, but the fact that Keshon Gilbert will be out moving forward is enough to at least consider the ‘dog in the first-round tilt. It also helps Lipscomb is arguably one of the best 14-seeds of all time as a top-85 team in KenPom that can shoot the crap out of the ball.

The Bisons did fail both of their power-conference tests in the non-con, but losing at Kentucky and at Arkansas is nothing to sneeze at. ISU isn’t quite as overwhelmingly athletic as those two squads, good news for the athletically-challenged Bisons.

Lipscomb can shoot, and that’s basically the only way you can score consistently against the Clones.

Lennie Acuff’s offense is a symphony of gorgeous motion filled with cutting and screening. He has four or five guys on the floor that can shoot the 3 at all times. Iowa State packs it in, and their on-ball havoc won’t bother the steady-handed Lipscomb guards who lead the Bisons’ No. 22-ranked turnover rate.

Lipscomb can hang around in this game — especially with Gilbert out.

The Pick: Lipscomb +14.5

Ky McKeon


For more coverage of the 2025 NCAA Tournament and Selection Sunday, make sure to check out our experts' live reactions to the bracket reveal and the Selection Sunday live show, where you can get their instant analysis on every matchup as well as some early insights to help you make your bets.

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