The Lipscomb Bisons take on the Iowa State Cyclones in the NCAA Tournament. Tip-off is set for 1:30 p.m. ET on TNT.
Iowa State is favored by 14.5 points on the spread with a moneyline of -1400. The total is set at 143.5 points.
Here are my Lipscomb vs. Iowa State predictions and college basketball picks for March 21, 2025.
Lipscomb vs Iowa State Prediction
My Pick: Lipscomb +15.5 or Better
My Lipscomb vs Iowa State best bet is on the Bisons spread, with the best odds currently available at DraftKings. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
Lipscomb vs Iowa State Odds, Spread, Pick
| Lipscomb Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+14.5 -110 | 143.5 -110o / -110u | +850 |
| Iowa State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-14.5 -110 | 143.5 -110o / -110u | -1400 |
- Lipscomb vs Iowa State spread: Iowa State -14.5
- Lipscomb vs Iowa State over/under: 143.5 points
- Lipscomb vs Iowa State moneyline: Iowa State -1400, Lipscomb +850
- Lipscomb vs Iowa State best bet: Lipscomb +15.5 or Better
My Lipscomb vs Iowa State NCAA Tournament Betting Preview
While no team is safe in March Madness, the 3-seeds typical feel safe. Over the course of history, 4-seeds lose their opening round game about 21% of the time. That's a whisker away from meaning one of the four teams on the four line gets bounced each year.
The 3-seeds however, lose their opener 15% of the time. That's not a monumental difference, but a clear shift that indicates there are many years without a 14-seed winning. In fact, from 2017 to 2019 and again in 2022 and 2023, the 14-seeds were swept. In 20 of the 39 tournaments with an expanded field, at least one 3-seed has lost in the Round of 64.
