The Louisville Cardinals take on the Virginia Tech Hokies in Blacksburg, VA. Tip-off is set for 9 p.m. ET on ACC Network.
Louisville is favored by 10.5 points on the spread with a moneyline of -625. The total is set at 145.5 points.
Here are my Louisville vs. Virginia Tech predictions and college basketball picks for February 25, 2025.
Louisville vs Virginia Tech Prediction
My Pick: Louisville -10.5 (Play to -11.5)
My Louisville vs Virginia Tech best bet is on the Cardinals spread, with the best odds currently available at DraftKings. For all of your college basketball bets, be sure to find the best lines by using our live NCAAB odds page.
Louisville vs Virginia Tech Odds
| Louisville Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-10.5 -120 | 145.5 -105 / -115 | -625 |
| Virginia Tech Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+10.5 +100 | 145.5 -105 / -115 | +455 |
- Louisville vs Virginia Tech spread: Louisville -10.5
- Louisville vs Virginia Tech over/under: 145.5 points
- Louisville vs Virginia Tech moneyline: Louisville -625, Virginia Tech +455
- Louisville vs Virginia Tech best bet: Louisville -10.5 (Play to -11.5)
Spread
I'm taking the Cardinals up to -11.5, as they're offense is in rhythm.
Moneyline
There's no value on the moneyline.
Over/Under
There's no value on the total.
My Pick: Louisville -10.5 (Play to -11.5)
Louisville vs Virginia Tech College Basketball Betting Preview
Let's keep it simple: Louisville has continued to dominate teams and it's getting deeper, which is surprising considering its injuries and the fact that teams normally make their rotations more compact as the season progresses.
Louisville's style of play has traveled, too, as it's crushed teams on the road. That's especially the case when it comes to inferior competition.
So, here's the Cards' results this season in true road games:
- Won by 14 at Florida State
- Won by 20 at Virginia
- Won by 4 at Pitt (when the Panthers were actually competent)
- Won by 24 at Syracuse
- Won by 25 at SMU
- Won by 26 at Boston College
- Won by 25 at NC State
- Won by 15 at Notre Dame
In this matchup, the Cardinals are going to crush Virginia Tech athletically — outside of Tobi Lawal, who's a freak and an exception on this roster.
Louisville is a fine-tuned offensive machine right now, as it's taking and making a ton of 3s.
The Cardinals have weathered the storm of early-season injuries and have officially sorted out their rotation, so I'm backing them here.
