Louisville vs Creighton Odds
| Louisville Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-2.5 +100 | 144.5 -110o / -110u | -142 |
| Creighton Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-2.5 -120 | 149.5 -110o / -110u | +120 |
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The 2025 NCAA Tournament field has been announced, and the Louisville Cardinals will take on the Creighton Bluejays in Round 1 of the South region. Here's everything you need to know about Louisville vs Creighton odds, spread, and more.
Louisville opened as a 2.5-point favorite over Creighton in the first round of the NCAA Tournament. The total is set at over/under 144.5 points scored by both teams combined.
Find out how No. 8-seeded Louisville and No. 9-seeded Creighton match up ahead of their opening round matchup.
Louisville vs Creighton Analysis
The Louisville Cardinals seem a bit underseeded here. Many bracketologists placed Louisville in the 6-7 seed range, but the committee didn’t respect the ACC, it seems.
The Cardinals are a heavy-volume 3-point shooting team (48% of their shots come from deep). But they struggle shooting, connecting on only 33% of shots from deep. We’ll see if Reyne Smith — their best shooter — returns after missing the ACC Tournament.
It’ll be interesting to see how stud point guard Chucky Hepburn attacks Creighton’s drop coverage defense, with 7-foot-1 anchor Ryan Kalkbrenner sitting in the paint.
Overall, I like Creighton here. The Bluejays deploy a similar offensive attack with an emphasis on shooting 3s (48% of their shots from deep). They convert on 33.9% of their 3s, led by point guard Steven Ashworth.
I can’t see Louisville containing Kalkbrenner. He’s the difference-maker here. Louisville relies on athletic 6-foot-11 center James Scott, and he’ll struggle to contain the veteran, Kalkbrenner.
Give me the Jays.
The Pick: Creighton +2.5
For more coverage of the 2025 NCAA Tournament and Selection Sunday, make sure to check out our experts' live reactions to the bracket reveal and the Selection Sunday live show, where you can get their instant analysis on every matchup as well as some early insights to help you make your bets.
