Louisville vs. Michigan State Odds
| Louisville Odds | +4 |
| Michigan State Odds | -4 |
| Over/Under | 137 |
| Date | Wednesday, Dec. 1 |
| Time | 7:15 p.m. ET |
| Channel | ESPN |
*Odds as of Wednesday morning.
The 2021 ACC/Big Ten Challenge wraps up on Wednesday night with five games, including Louisville vs. Michigan State and Michigan vs. North Carolina as the marquee matchups.
As of Wednesday at noon ET, our betting tools are yet to track much in the way of sharp action associated with Michigan vs. North Carolina.
However, when it comes to Louisville vs. Michigan, big bets from respected players are already influencing the line for tonight's ACC/Big Ten Challenge matchup.
Let's take a deeper look at the side of Louisville vs. Michigan that is attracting significant money from sharp bettors.
Louisville vs. Michigan State Sharp Betting Pick
Louisville opened as a 5-point underdog against Michigan State, and 60% of the spread bets have landed on the Cardinals thus far.
