2021 NCAA Tournament Odds: Spreads, Over/Unders For Every First-Round Game

2021 NCAA Tournament Odds: Spreads, Over/Unders For Every First-Round Game article feature image
Credit:

Michael Hickey/Getty Images. Pictured: Ayo Dosunmu.

  • 2021 NCAA Tournament odds are out, complete with spreads and totals from sportsbooks.
  • We've outlined every spread, over/under and moneyline below for the First Four games, and every other first-round matchup that's set.

Let the madness begin!

Find NCAA Tournament odds for every First Four and Round of 64 matchup outlined below.

Note that lines are as of 8 p.m. ET and via PointsBet, where you can bet $20 to win $300 on any college basketball moneyline.

» Compare real-time odds here

March Madness Odds


Skip to:East | West | Midwest | South


First Four

#16 Norfolk State vs. #16 Appalachian State

  • Spread: App State -3
  • Total: 135.5
  • ML: +125/-145

#11 Drake vs. #11 Wichita State

  • Spread: Wichita State -2.5
  • Total: 139.5
  • ML: +115/-136

#16 Mount St. Mary's vs. #16 Texas Southern

  • Spread: Texas Southern -2
  • Total: 134
  • ML: +115/-136

#11 Michigan State vs. #11 UCLA

  • Spread: Michigan State -1
  • Total: 137.5
  • ML: -105/-115

West Region

#8 Oklahoma vs. #9 Missouri

  • Spread: Oklahoma -2
  • Total: 140.5
  • ML: -131/+110

#5 Creighton vs. #12 UC Santa Barbara

  • Spread: Creighton -7.5
  • Total: 140.5
  • ML: -301/+240

#4 Virginia vs. #13 Ohio

  • Spread: Virginia -10
  • Total: 132.5
  • ML: -530/+390

#3 Kansas vs. #14 Eastern Washington

  • Spread: Kansas -11.5
  • Total: 142.5
  • ML: -741/+520

#7 Oregon vs. #10 VCU

  • Spread: Oregon -5.5
  • Total: 138
  • ML: -261/+205

#2 Iowa vs. #15 Grand Canyon

  • Spread: Iowa -15.5
  • Total: 144.5
  • ML: -1500/+900

South Region

#1 Baylor vs. #16 Hartford

  • Spread: Baylor -26
  • Total: 142.5
  • ML: N/A

#8 North Carolina vs. #9 Wisconsin

  • Spread: North Carolina -2
  • Total: 138.5
  • ML: -121/+100

#5 Villanova vs. #12 Winthrop

  • Spread: Villanova -7
  • Total: 139
  • ML: -285/+225

#4 Purdue vs. #13 North Texas

  • Spread: Purdue -7.5
  • Total: 126
  • ML: -320/+245
The must-have app for college hoops bettors

Custom scoreboard for your bets

Free picks from experts

Live odds for every game

#6 Texas Tech vs. #11 Utah St.

  • Spread: Texas Tech -4.5
  • Total: 131.5
  • ML: -216/+170

#3 Arkansas vs. #14 Colgate

  • Spread: Arkansas -9.5
  • Total: 158.5
  • ML: -470/+350

#7 Florida vs. #10 Virginia Tech

  • Spread: Florida -1
  • Total: 137.5
  • ML: -121/+100

#2 Ohio State vs. #15 Oral Roberts

  • Spread: Ohio St. -16.5
  • Total: 154.5
  • ML: -2253/+1175

Midwest Region

#1 Illinois vs. #16 Drexel

  • Spread: Illinois -22.5
  • Total: 144
  • ML: N/A

#8 Loyola Chicago vs. #9 Georgia Tech

  • Spread: Loyola Chicago -2.5
  • Total: 127
  • ML: -140/+120

#5 Tennesse vs. #12 Oregon State

  • Spread: Tennessee -8.5
  • Total: 134
  • ML: -380/+290

#4 Oklahoma State vs. #13 Liberty

  • Spread: Oklahoma St. -9
  • Total: 145
  • ML: -460/+340
Photo by William Purnell/Icon Sportswire via Getty Images. Pictured: Cade Cunningham, Oklahoma State

#6 San Diego State vs. #11 Syracuse

  • Spread: San Diego St. -2
  • Total: 138
  • ML: -145/+125

#3 West Virginia vs. #14 Morehead State

  • Spread: West Virginia -12.5
  • Total: 137.5
  • ML: -851/+580

#7 Clemson vs. #10 Rutgers

  • Spread: Rutgers -1
  • Total: 127
  • ML: -105/-115

#2 Houston vs. #15 Cleveland St.

  • Spread: Houston -19
  • Total: 135
  • ML: N/A

East Region

#8 LSU vs. #9 St. Bonaventure

  • Spread: LSU -1.5
  • Total: 144.5
  • ML: -125/+105

#5 Colorado vs. #12 Georgetown

  • Spread: Colorado -5
  • Total: 138.5
  • ML: -200/+170

#4 Florida State vs. #13 UNC Greensboro

  • Spread: Florida St. -11
  • Total: 145.5
  • ML: -680/+480

#3 Texas vs. #14 Abilene Christian

  • Spread: Texas -8.5
  • Total: 140
  • ML: -440/+330

#7 Connecticut vs. #10 Maryland

  • Spread: Connecticut -2
  • Total: 130.5
  • ML: -136/+115

#2 Alabama vs. #15 Iona

  • Spread: Alabama -17
  • Total: 144.5
  • ML: -2000/+1100
About the Author
The hub for everything bettors need to know about every sport.

Follow Action Network Staff @ActionNetworkHQ on Twitter/X.

This site contains commercial content. We may be compensated for the links provided on this page. The content on this page is for informational purposes only. Action Network makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event.