Saint Mary’s vs Vanderbilt Odds, Opening Spread, Predictions for 2025 NCAA Tournament

Saint Mary’s vs Vanderbilt Odds, Opening Spread, Predictions for 2025 NCAA Tournament article feature image
Credit:

Credit: Getty Images. Pictured: Saint Mary’s Gaels men’s basketball head coach Randy Bennett.

Saint Mary's vs Vanderbilt Odds

Saint Mary's Logo
Friday, March 21
3:15 p.m. ET
truTV
Vanderbilt Logo
Saint Mary's Odds
SpreadTotalMoneyline
-4.5
-110
135.5
-110o / -110u
-218
Vanderbilt Odds
SpreadTotalMoneyline
+4.5
-110
135.5
-110o / -110u
+180
Odds via DraftKings . Get up-to-the-minute NCAAB odds here.
DraftKings  Logo

Click Here to Bet Saint Mary's Instantly at DraftKings! | Click Here to Bet Vanderbilt Instantly at DraftKings!

The 2025 NCAA Tournament field has been announced, and the Saint Mary's Gaels will take on the Vanderbilt Commodores in Round 1 of the East region. Here's everything you need to know about Saint Mary's vs Vanderbilt odds, spread, and more.

Saint Mary's opened as a 4.5-point favorite over Vanderbilt in the first round of the NCAA Tournament. The total is set at over/under 135.5 points scored by both teams combined.

Find out how No. 7-seeded Saint Mary's and No. 10-seeded Vanderbilt match up ahead of their opening round matchup.


Saint Mary's vs Vanderbilt Analysis

I find this to be one of the more interesting matchups in the Round of 64. Vanderbilt limped into the dance, dropping three straight games but did enough to earn a 10-seed.

Remember when Drake beat Vanderbilt? This game feels similar. The Commodores played right into the hands of the deliberate-paced Bulldogs. I think the Gaels do the same thing.

The biggest edge for Randy Bennett’s squad is on the glass. The Gaels grab offensive rebounds boards on 40% of their misses, which ranks second nationally. Meanwhile, Vanderbilt ranks outside the top 120 in defensive rebound rate.

In this contrasting style matchup, it’ll likely come down to which team controls the tempo. I think Saint Mary’s will crush Vandy in the shot-volume battle, thus leading to drawn-out possessions.

Give me the Gaels laying the points.

The Pick: Saint Mary's -5.5

Sean Paul


For more coverage of the 2025 NCAA Tournament and Selection Sunday, make sure to check out our experts' live reactions to the bracket reveal and the Selection Sunday live show, where you can get their instant analysis on every matchup as well as some early insights to help you make your bets.

About the Author
Action Network is a team of seasoned sports betting experts specializing in a broad range of sports, from the NFL and NBA to less mainstream options like cricket and darts. Their staff includes well-known analysts like Sean Koerner and Stuckey, recognized for their accurate predictions and deep sports knowledge. The team is dedicated to delivering expert analysis and daily best bets, ensuring bettors are well-informed across all major sports.

Follow Action Network Staff @ActionNetworkHQ on Twitter/X.

This site contains commercial content. We may be compensated for the links provided on this page. The content on this page is for informational purposes only. Action Network makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event.