The Stanford Cardinal take on the Duke Blue Devils in Durham, NC. Tip-off is set for 4 p.m. ET on ABC.
Duke is favored by 18.5 points on the spread with a moneyline of -3000. The total is set at 140.5 points.
Here are my Stanford vs. Duke predictions and college basketball picks for February 15, 2025.
Stanford vs Duke Prediction
My Pick: PASS | Lean Stanford +19.5
My Stanford vs Duke best bet is on the Cardinal spread, with the best odds currently available at DraftKings. For all of your college basketball bets, find the best lines using our live NCAAB odds page.
Stanford vs Duke Odds, Spread, Pick
| Stanford Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+18.5 -110 | 140.5 -110 / -110 | +1400 |
| Duke Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-18.5 -110 | 140.5 -110 / -110 | -3000 |
- Stanford vs Duke spread: Duke -18.5
- Stanford vs Duke over/under: 140.5 points
- Stanford vs Duke moneyline: Duke -3000, Stanford +1400
- Stanford vs Duke best bet: PASS | Lean Stanford +19.5
My Stanford vs Duke College Basketball Betting Preview
First things first, it’s important to mention that Stanford is lifeless on the road. The Cardinal rank 355th nationally in Haslametrics' away-from-home metric, and they’re 1-5 in ACC road games with a win over the corpse of North Carolina, an eight-point loss to Georgia Tech and four double-digit losses.
I can’t say I love Stanford’s chances of hanging with the elite Blue Devils at Cameron Indoor.
That said, the schematic matchup isn’t awful.
Stanford funnels most of its offense through Maxime Raynaud, and the Cardinal certainly won’t generate anything on pure post-ups or hard rolls against Duke’s lengthy, nearly impenetrable interior defense — you can’t score inside against Cooper Flagg and Khaman Maluach.
That said, I think your best chance at cracking Duke’s nation-best defense is over the top. Raynaud is a stretch big, and the Cardinal will utilize him in pick-and-pop and inside-out actions, which Duke isn’t immune to giving up.
I also think you can potentially exploit Maluach by moving him around and making him defend in space.
On the other end of the court, the key to stopping Duke is limiting Jon Scheyer’s relentless perimeter stagger screening actions. Surprisingly, Stanford is among the nation’s best at defending those actions (1.3 points per game allowed, 12th nationally, per Synergy).
That said, Stanford’s dribble-penetration and isolation defense has been lifeless. Flagg can take care of the latter, and if Duke finds some success on the former, the Blue Devils should be able to drive and dish all night, eventually opening up those key catch-and-shoot opportunities.
I lean toward Stanford to cover the three-touchdown spread on Saturday, but I don’t trust the Cardinal on the road, and it would take some heroic shot-making from Reynaud to make it happen.
For what it’s worth, he’s only shooting 26% on pick-and-pop actions this year, and I can’t imagine that number will jump cross-country in a hostile environment.
