Sweet 16 Odds, Lines, Spreads, Predictions for Every Game | March Madness 2024

Sweet 16 Odds, Lines, Spreads, Predictions for Every Game | March Madness 2024 article feature image
Credit:

Photo by Joe Murphy via Getty Images. Pictured: The Houston Cougars celebrate advancing to the Sweet 16 as we preview the next round of March Madness with Sweet 16 odds, lines, spreads, predictions and picks for every game.

The first weekend of March Madness is complete. And after a few days off, we'll move into the Sweet 16 on Thursday and Friday.

But you don't have to wait to start breaking down the Sweet 16 odds and Sweet 16 predictions. Here are the odds and our betting expert's predictions for the point spread, total and final score for every game.

You'll also find a running tracker of all of our expert picks for each Sweet 16 game based on the latest 2024 March Madness odds.

Sweet 16 Odds, Lines, Spreads, Predictions for Every Game

GameOdds, SpreadPrediction
Arizona -7
UConn -10
UNC -4
Iowa State -2.5
Marquette -6.5
Purdue -4.5
Houston -3.5
Tennessee -2.5
Odds via bet365. Always shop for the best price using our NCAAB Odds page, which automatically surfaces the best lines for every game.

No. 6 Clemson vs No. 2 Arizona Odds, Prediction

Clemson Logo
Thursday, Mar 28
7:09pm ET
CBS
Arizona Logo
Clemson Odds
SpreadTotalMoneyline
+7
-110
152
-110o / -110u
+250
Arizona Odds
SpreadTotalMoneyline
-7
-110
152
-110o / -110u
-310
Odds via bet365. Get up-to-the-minute NCAAB odds here.
bet365 Logo

Clemson vs Arizona Predictions:
Arizona -6 | Over/Under 151 | Final Score: Arizona 79, Clemson 73

No. 5 San Diego State vs No. 1 UConn Odds, Prediction

San Diego State Logo
Thursday, Mar 28
7:39pm ET
truTV
UConn Logo
San Diego State Odds
SpreadTotalMoneyline
+10
-110
135
-110o / -110u
+370
UConn Odds
SpreadTotalMoneyline
-10
-110
135
-110o / -110u
-485
Odds via bet365. Get up-to-the-minute NCAAB odds here.
bet365 Logo

San Diego State vs UConn Predictions:
UConn -9 | Over/Under 135 | Final Score: UConn 72, San Diego State 63

No. 4 Alabama vs No. 1 UNC Odds, Prediction

Alabama Logo
Thursday, Mar 28
9:39pm ET
CBS
UNC Logo
Alabama Odds
SpreadTotalMoneyline
+4
-110
173.5
-110o / -110u
+165
UNC Odds
SpreadTotalMoneyline
-4
-110
173.5
-110o / -110u
-200
Odds via bet365. Get up-to-the-minute NCAAB odds here.
bet365 Logo

Alabama vs UNC Predictions:
UNC -1 | Over/Under 158.5 | Final Score: UNC 80, Alabama 79

No. 3 Illinois vs No. 2 Iowa State Odds, Prediction

Illinois Logo
Thursday, Mar 28
10:09pm ET
TBS/truTV
Iowa State Logo
Illinois Odds
SpreadTotalMoneyline
+2.5
-110
146
-110o / -110u
+125
Iowa State Odds
SpreadTotalMoneyline
-2.5
-110
146
-110o / -110u
-150
Odds via bet365. Get up-to-the-minute NCAAB odds here.
bet365 Logo

Illinois vs Iowa State Predictions:
Iowa State -1 | Over/Under 142 | Final Score: Iowa State 72, Illinois 71

No. 11 NC State vs No. 2 Marquette Odds, Prediction

NC State Logo
Friday, Mar 29
7:09pm ET
CBS
Marquette Logo
NC State Odds
SpreadTotalMoneyline
+6.5
-110
150.5
-110o / -110u
+235
Marquette Odds
SpreadTotalMoneyline
-6.5
-110
150.5
-110o / -110u
-290
Odds via bet365. Get up-to-the-minute NCAAB odds here.
bet365 Logo

NC State vs Marquette Predictions:
Marquette -8.5 | Over/Under 145.5 | Final Score: Marquette 77, NC State 69

No. 5 Gonzaga vs No. 1 Purdue Odds, Prediction

Gonzaga Logo
Friday, Mar 29
7:39pm ET
TBS/truTV
Purdue Logo
Gonzaga Odds
SpreadTotalMoneyline
+4.5
-110
154
-110o / -110u
+165
Purdue Odds
SpreadTotalMoneyline
-4.5
-110
154
-110o / -110u
-200
Odds via bet365. Get up-to-the-minute NCAAB odds here.
bet365 Logo

Gonzaga vs Purdue Predictions:
Purdue -4.5 | Over/Under 152.5 | Final Score: Purdue 79, Gonzaga 74

No. 4 Duke vs No. 1 Houston Duke Odds, Prediction

Duke Logo
Friday, Mar 29
9:39pm ET
CBS
Houston Logo
Duke Odds
SpreadTotalMoneyline
+3.5
-106
133.5
-115o / -105u
+140
Houston Odds
SpreadTotalMoneyline
-3.5
-114
133.5
-115o / -105u
-170
Odds via FanDuel. Get up-to-the-minute NCAAB odds here.
FanDuel Logo

Houston vs Duke Predictions:
Houston -4 | Over/Under 134.5 | Final Score: Houston 70, Duke 65

No. 3 Creighton vs No. 2 Tennessee Odds, Prediction

Creighton Logo
Friday, Mar 29
10:09pm ET
TBS/truTV
Tennessee Logo
Creighton Odds
SpreadTotalMoneyline
+2.5
-110
144
-110o / -110u
+125
Tennessee Odds
SpreadTotalMoneyline
-2.5
-110
144
-110o / -110u
-150
Odds via bet365. Get up-to-the-minute NCAAB odds here.
bet365 Logo

Creighton vs Tennesee Predictions:
Tennessee -4 | Over/Under 140.5 | Final Score: Tennessee 72, Creighton 68

This site contains commercial content. We may be compensated for the links provided on this page. The content on this page is for informational purposes only. Action Network makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event.