- The Arizona Cardinals begin the regular season against the Buffalo Bills, with kickoff set for 1 p.m. ET at Highmark Stadium in Orchard Park, N.Y.
- The Bills are favored by 5.5 points over the Cardinals, with the game total set at 48.5.
- Kyler Murray is healthy under center for Arizona, while the Bills offense will look very different without two of Josh Allen's key receivers from last season.
It's time for my Cardinals vs. Bills predictions.
I've thought we were getting a good number on Buffalo since the lines were set when the schedule was released back in May. It's gotten a bit complicated with the line moving up to -6.5, but we'll break that down below. Marvin Harrison Jr. will make his NFL debut for Arizona as the reigning fourth overall pick.
Arizona Cardinals vs. Buffalo Bills Picks
SPREAD
We have no pick on the Cardinals-Bills spread. Arizona is a popular NFL pick, though.
MONEYLINE
We have no bet on the moneyline.
TOTAL
With high winds expected in Orchard Park today, our betting pick is on the under.
Cardinals vs. Bills Pick: Under 47.5
Cardinals vs. Bills Odds
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+6.5 -105 | 46.5 -110o / -110u | +240 |
| Bills Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-6.5 -115 | 46.5 -110o / -110u | -300 |
- Cardinals vs. Bills Point Spread: Cardinals +6.5 | Bills -6.5
- Cardinals vs. Bills Total: Over/Under 46.5
- Cardinals vs. Bills Moneyline: Cardinals +240 | Bills -300
- 62% of bets and 56% of the money are on Arizona to cover the spread.
- 73% of bets and 48% of the money are on the under.
- 91% of bets and 95% of the money on the moneyline are on Buffalo.
How To Watch Arizona vs. Buffalo
| Location: | Highmark Stadium in Orchard Park, N.Y. |
| Date: | Sunday, Sept. 8 |
| Kickoff Time: | 1 p.m. ET |
| TV / Streaming: | CBS |
Bills vs. Bills is scheduled for 1 p.m. ET live from Highmark Stadium on Sunday. The game is live on CBS and other streaming platforms, such as YouTube TV.
NFL Weather Week 1 for Sunday's Game
How To Make NFL Picks for Cardinals vs. Bills
By Simon Hunter
If you're a fan of "The Favorites," then you'll know this was a line I liked right when lines came out after the schedule was released in May. I thought we were getting a good number on the Bills, but I got a bunch of sharp calls that bullied me into getting off of my position.
I really like the Cardinals, but there are too many question marks here. Kyler Murray is back and Marvin Harrison Jr. is in, but I'm still not entirely sold. I want to see Murray's connection with Harrison before backing Arizona.
The line moving from 5.5 to 6.5 this week has made this pick complicated. The potential for a tease on the Bills is now very high. I initially liked the Bills, but I'm going to sit this one out and see how the matchup plays out.
By Kevin Roth
This likely ends up as the windiest game of Week 1.
In full transparency, I prefer hitting wind unders with sustained winds of 20 mph or greater, and this game likely falls just a hair short of that criteria. That being said, I still think we'll see it impacting one or two deeper throws or long field goals, and the difference between an over and an under can be one field goal or one would-be-touchdown ball that hangs up in the wind.
I expect winds in Orchard Park to be consistently 15-20 mph with wind gusts of 20-25 mph. It certainly won't impact every play, but it might just be enough to tilt the odds in our favor.
Pick: Under 47.5
