The Buffalo Bills (10-3) and Detroit Lions (12-1) will face off in NFL Week 15 at 4:25 p.m. ET from Ford Field in Detroit. The game will be broadcast live on CBS and can be streamed on Paramount+.
Let's get into my Lions vs Bills predictions and NFL picks.
The Lions are favored by 2.5 points with the game total set at 54.5 points scored. The Lions are -145 favorites to win outright, while the Bills are +120 to pull off the upset.
The Bills lost 44-42 last week to the Rams, which snapped their 7-game winning streak. In defeat, Josh Allen threw for 342 yards and 3 touchdowns, and he added 82 rushing yards and 3 rushing TDs. The Lions won 34-31 over the Packers last week for their 11th straight win. Jared Goff threw 3 touchdown passes, 2 of which went to Tim Patrick. Six Lions receivers had at least 5 receptions.
Bills vs. Lions Prediction
Spread
I see value on the Bills at +2.5, although I'm hoping this number gets to +3. Still, I'll back the Bills here in a matchup that I think benefits them.
Over/Under
I also do not have a pick for the total.
My Pick: Bills +2.5
Bills vs. Lions Odds, Spread, Over/Under
| Bills Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+2.5 -105 | 54.5 -110o / -110u | +120 |
| Lions Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-2.5 -115 | 54.5 -110o / -110u | -145 |
- Bills vs. Lions spread: Lions -2.5
- Bills vs. Lions over/under: 54.5 points scored
- Bills vs. Lions moneyline: Lions -145, Bills +120
- Bills vs. Lions best bet: Bills +2.5
MyBills vs. Lions best bet is on Buffalo. For all of your NFL bets, be sure to find the best lines by using our live NFL odds page.
Buffalo Bills vs. Detroit Lions Preview
I’m hoping we get to Bills +3 on the spread. Getting a field goal on the road with Buffalo would be great.
I’ve been jonesing for this spot to fade the Lions because I’ve been waiting for a top-tier quarterback and healthy offense to face their defense. Detroit has been fortunate with its matchups this season, and this defense could get picked apart.
The Lions defense plays aggressive man coverage, and its single-high-safety looks could get picked apart by Josh Allen. We hear often about how Jared Goff thrives indoors, but Allen is 9-2-1 against the spread (ATS) in his career when playing indoors. He covers at an 81.8% rate and by 10 points per game.
The Bills play a ton of zone defense and don’t blitz much. That’s what you want to do against a Lions offense that is going to have success running the ball.
The Lions have struggled against mobile quarterbacks this season, and Allen is among the most mobile in the NFL. He’ll be very active using his legs here, and that will create explosive plays for the Bills offense.
Allen is the best quarterback the Lions have faced this season. They have one loss and are 6-1 against the spread in one-possession games. They blew out Mac Jones, Mason Rudolph and Anthony Richardson. This is a step up that the Lions haven’t seen this season.
By the way, Allen is 27-14-2 (66%) ATS when he’s an underdog or favorite of fewer than three points. On the road, he’s 18-8-2 in that situation.
Teams with a win percentage north of 90% in December are 21-48-2 since 2003. That’s a 30% rate, and those teams fail to cover by 3.5 points per game.
Also, teams averaging more than 28 points per game with a win percentage north of 90% are 8-31-2 against the spread in December.
I love this matchup for the Bills on both sides of the ball. I think Goff will make a mistake or two that will cost Detroit and allow the Bills to bounce back after a tough loss to the Rams.
My Pick: Bills +2.5
Lions vs Bills Betting Trends
NFL Weather
