The Buffalo Bills (10-2) and Los Angeles Rams (6-6) will face off in NFL Week 14 at 4:25 p.m. ET from SoFi Stadium in Inglewood, Calif. The game will be live on FOX and can be streamed on YouTube TV.
Let's get into my Bills vs. Rams predictions and NFL picks for Week 14 below, plus the latest odds, betting trends, injuries and more.
Bills vs. Rams odds have the Bills as -192 moneyline favorites and Rams as +160 underdogs. The over/under is 49.5 (-112o / -108u). The Bills 3.5-point favorites on the spread over the Rams (-3.5, -118).
Buffalo is coming off a huge win over the San Francisco 49ers on Sunday Night Football, clinching the AFC East for the fifth straight season. Los Angeles, meanwhile, eked out a win over the Saints last week and enter Week 14 one game behind the Seattle Seahawks in the NFC West.
Bills vs. Rams Predictions
Against the Spread
Everyone is in love with the Bills right now, and rightfully so.
However, this is a spot — coming off a big win on SNF, clinching the AFC East and traveling west — to back the Rams.
I got L.A. at +4.5 before the line moved.
Over/Under
Like the moneyline, I'm passing on the game total.
My Pick: Rams +3.5 (-102; DraftKings)
Bills vs. Rams Odds, Spread, Over/Under
| Buffalo Bills Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
-3.5 -118 | 49.5 -112o / -108u | -192 |
| Los Angeles Rams Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
+3.5 -102 | 49.5 -112o / -108u | +160 |
- Bills vs. Rams spread: Bills -3.5 (-118), Rams +3.5 (-102)
- Bills vs. Rams over/under: 49.5 (-112o / -108u)
- Bills vs. Rams moneyline: Bills -192, Rams +160
- Bills vs. Rams best bet: Rams +3.5 (-102)
MyBills vs. Rams best bet is on the Rams against the spread, with the best odds currently available at bet365. For all of your NFL bets, be sure to find the best lines by using our live NFL odds page.
Bills vs. Rams Preview, Prediction for Week 14
The Bills have been great, but we’re probably at the top of the market on them.
They laid less points just a couple of week ago on the road against the Colts, who had a beat-up offensive line. I have the Colts power-rated lower than the Rams.
This is also not a great spot on the surface for the Bills, who beat the Chiefs two weeks ago and then blew out the 49ers on Sunday Night Football. Having clinched the AFC East, Buffalo will travel across the country for this game.
The Rams are playing for their season. At 6-6, they have very little margin for error in the competitive NFC West and trail the first-place Seahawks by one game.
This is a max-effort spot for Los Angeles, and I think you’ll see a strong outing from Sean McVay’s team.
There are a few things that favor the Rams in terms of the matchup. The Bills play a zone-heavy defense that actually has been below average against the pass if you remove turnovers. That benefits Matthew Stafford, whose numbers are significantly better against zone coverage and he will have a healthy receiving corps.
The Rams' offensive line will also trend upward the rest of the season. They’ve added almost one starter every game over the past few weeks and are now close to full strength. I think that continuity will start to really benefit the offense.
The Bills don’t blitz a ton either, so Stafford’s lack of mobility isn’t a real concern for me.
The Rams defense isn’t great, but they can generate pressure on Allen. More importantly, Los Angeles is zone-heavy and will need to be against Allen, who torches man coverage — 17 of his 20 touchdown passes this season have come against man coverage.
Allen has a turnover or two coming his way. Last year, he had a 6% big-time throw rate and 3% turnover-worthy play rate. He had 33 touchdowns and 18 interceptions.
Those numbers are the same this year, but he has 20 touchdowns to five interceptions. The Bills also lead the NFL with a +17 turnover differential.
The Bills have converted 86% of their fourth-down attempts this season, while their opponents are 10-of-24 (41%). There’s reason to believe that some regression is coming here.
My Pick: Rams +3.5 (-102)
Bills vs. Rams Betting Trends
Bills Trends
- Bills are 4-1 in their last 5 games against the spread
- Bills are 4-2 in their road games against the spread
- The totals have gone OVER in 2 of Bills' last 5 games
Rams Trends
- Rams are 2-3 in their last 5 games against the spread
- The totals have gone OVER in 2 of Rams' last 5 games
- The totals have gone OVER in 3 of Rams' 6 last games at home
Bills vs Rams Latest Injuries
Bills Injuries
| Player | Status |
|---|---|
| OT Tyler Grable | Out (groin) |
| DT DeWayne Carter | Questionable (wrist) |
| WR Keon Coleman | Questionable (wrist) |
| TE Dalton Kincaid | Questionable (knee) |
| TE Quentin Morris | Questionable (shoulder/groin) |
Rams Injuries
| Player | Status |
|---|---|
| TE Tyler Higbee | Out (knee) |
| OL KT Leveston | Out (ankle) |
| LB Jared Verse | Questionable (ankle) |
| OL Alaric Jackson | Questionable (foot) |
