NFL Odds, Picks, Predictions for Every Game: Week 4 NFL Schedule

NFL Odds, Picks, Predictions for Every Game: Week 4 NFL Schedule article feature image
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Getty Images. Pictured: The NFL logo at midfield.

Our experts have taken a look up and down the NFL Week 4 schedule, and they've come away with their best bets for every game.

The tightest spread at the moment is in Eagles vs. Buccaneers, where the Eagles are currently just 1-point favorites (-1) over the Bucs. The biggest spread is in Patriots vs. 49ers, as San Francisco is a 10.5-point favorite (-10.5) against New England. The highest over/under is in Commanders vs. Cardinals at 48.5 points, and the lowest total is the over/under 37 in both Browns vs. Raiders and Titans vs. Dolphins.

But those are just the superlatives. Let's get to the Week 4 NFL odds, our expert picks, and NFL predictions for every game.

Week 4 NFL Predictions

NFL Odds, Spreads Today

  • Broncos vs. Jets Spread: Jets -8
  • Bengals vs. Panthers Spread: Bengals -4.5
  • Eagles vs. Buccaneers Spread: Eagles -1
  • Rams vs. Bears Spread: Bears -3
  • Saints vs. Falcons Spread: Falcons -2.5
  • Jaguars vs. Texans Spread: Texans -5.5
  • Vikings vs. Packers Spread: Packers -2.5
  • Steelers vs. Colts Spread: Steelers -2.5
  • Patriots vs. 49ers Spread: 49ers -10.5
  • Commanders vs. Cardinals Spread: Cardinals -3.5
  • Chiefs vs. Chargers Spread: Chiefs -7.5
  • Browns vs. Raiders Spread: Browns -2.5
  • Bills vs. Ravens Spread: Ravens -2.5
  • Titans vs. Dolphins Spread: Dolphins -2.5
  • Seahawks vs. Lions Spread: Lions -3.5

Week 4 NFL Schedule

Denver Broncos at New York Jets

Broncos Logo
Sunday, Sep 29
1 p.m. ET
CBS
Jets Logo
Broncos Odds
SpreadTotalMoneyline
+8
-110
39
-110o / -110u
+350
Jets Odds
SpreadTotalMoneyline
-8
-110
39
-110o / -110u
-410
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Broncos vs. Jets Spread: Jets -8
  • Broncos vs. Jets Over/Under: 39.5 points
  • Broncos vs. Jets Moneyline: Jets -425, Broncos +325
  • Broncos vs. Jets Pick, Prediction: Garrett Wilson player prop

Cincinnati Bengals at Carolina Panthers

Bengals Logo
Sunday, Sep 29
1 p.m. ET
FOX
Panthers Logo
Bengals Odds
SpreadTotalMoneyline
-5
-110
47
-112o / -108u
-218
Panthers Odds
SpreadTotalMoneyline
+5
-110
47
-112o / -108u
+185
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Bengals vs. Panthers Spread: Bengals -4.5
  • Bengals vs. Panthers Over/Under: 47 points
  • Bengals vs. Panthers Moneyline: Bengals -210, Panthers +180
  • Bengals vs. Panthers Pick, Prediction: Bengals to cover the spread

Philadelphia Eagles at Tampa Bay Buccaneers

Eagles Logo
Sunday, Sep 29
1 p.m. ET
FOX
Buccaneers Logo
Eagles Odds
SpreadTotalMoneyline
-1
-110
42
-110o / -110u
-115
Buccaneers Odds
SpreadTotalMoneyline
+1
-110
42
-110o / -110u
+100
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Eagles vs. Buccaneers Spread: Eagles -1
  • Eagles vs. Buccaneers Over/Under: 42
  • Eagles vs. Buccaneers Moneyline: Eagles -121, Bucs +100
  • Eagles vs. Buccaneers Pick, Prediction: Bucs to cover the spread

Los Angeles Rams at Chicago Bears

Rams Logo
Sunday, Sep 29
1 p.m. ET
FOX
Bears Logo
Rams Odds
SpreadTotalMoneyline
+3
-115
40.5
-108o / -112u
+125
Bears Odds
SpreadTotalMoneyline
-3
-105
40.5
-108o / -112u
-148
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Rams vs. Bears Spread: Bears -3
  • Rams vs. Bears Over/Under: 40.5 points
  • Rams vs. Bears Moneyline: Bears -160, Rams +135
  • Rams vs. Bears Pick, Prediction: Bears to cover the spread

New Orleans Saints at Atlanta Falcons

Saints Logo
Sunday, Sep 29
1 p.m. ET
FOX
Falcons Logo
Saints Odds
SpreadTotalMoneyline
+2.5
-102
41
-110o / -110u
+120
Falcons Odds
SpreadTotalMoneyline
-2.5
-118
41
-110o / -110u
-142
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Saints vs. Falcons Spread: Falcons -2.5
  • Saints vs. Falcons Over/Under: 41.5 points
  • Saints vs. Falcons Moneyline: Falcons -141, Saints +120
  • Saints vs. Falcons Pick, Prediction: Falcons to cover the spread

Jacksonville Jaguars at Houston Texans

Jaguars Logo
Sunday, Sep 29
1 p.m. ET
CBS
Texans Logo
Jaguars Odds
SpreadTotalMoneyline
+6
-112
44.5
-112o / -108u
+205
Texans Odds
SpreadTotalMoneyline
-6
-108
44.5
-112o / -108u
-238
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Jaguars vs. Texans Spread: Texans -5.5
  • Jaguars vs. Texans Over/Under: 44.5 points
  • Jaguars vs. Texans Moneyline: Texans -225, Jaguars +190
  • Jaguars vs. Texans Pick, Prediction: Jaguars to cover the spread

Minnesota Vikings at Green Bay Packers

Vikings Logo
Sunday, Sep 29
1 p.m. ET
CBS
Packers Logo
Vikings Odds
SpreadTotalMoneyline
+3
-118
44
-112o / -108u
+124
Packers Odds
SpreadTotalMoneyline
-3
-102
44
-112o / -108u
-145
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Vikings vs. Packers Spread: Packers -3
  • Vikings vs. Packers Over/Under: 44 points
  • Vikings vs. Packers Moneyline: Packers -145, Vikings +120
  • Vikings vs. Packers Pick, Prediction: Vikings to cover the spread

Pittsburgh Steelers at Indianapolis Colts

Steelers Logo
Sunday, Sep 29
1 p.m. ET
CBS
Colts Logo
Steelers Odds
SpreadTotalMoneyline
-2
-112
40
-110o / -110u
-130
Colts Odds
SpreadTotalMoneyline
+2
-108
40
-110o / -110u
+110
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Steelers vs. Colts Spread: Steelers -2.5
  • Steelers vs. Colts Over/Under: 40 points
  • Steelers vs. Colts Moneyline: Steelers -130, Colts +110
  • Steelers vs. Colts Pick, Prediction: Colts to cover the spread

New England Patriots at San Francisco 49ers

Patriots Logo
Sunday, Sep 29
4:05 p.m. ET
FOX
49ers Logo
Patriots Odds
SpreadTotalMoneyline
+10.5
-115
40.5
-110o / -110u
+400
49ers Odds
SpreadTotalMoneyline
-10.5
-105
40.5
-110o / -110u
-500
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Patriots vs. 49ers Spread: 49ers -10.5
  • Patriots vs. 49ers Over/Under: 41.5 points
  • Patriots vs. 49ers Moneyline: 49ers -500, Patriots +400
  • Patriots vs. 49ers Pick, Prediction: Patriots to cover the spread

Washington Commanders at Arizona Cardinals

Commanders Logo
Sunday, Sep 29
4:05 p.m. ET
FOX
Cardinals Logo
Commanders Odds
SpreadTotalMoneyline
+3.5
-118
49
-110o / -110u
+150
Cardinals Odds
SpreadTotalMoneyline
-3.5
-102
49
-110o / -110u
-175
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Commanders vs. Cardinals Spread: Cardinals -3.5
  • Commanders vs. Cardinals Over/Under: 48.5 points
  • Commanders vs. Cardinals Moneyline: Cardinals -175, Commanders +150
  • Commanders vs. Cardinals Pick, Prediction: Cardinals to cover the spread

Kansas City Chiefs at Los Angeles Chargers

Chiefs Logo
Sunday, Sep 29
4:25 p.m. ET
CBS
Chargers Logo
Chiefs Odds
SpreadTotalMoneyline
-7
-110
41.5
-112o / -108u
-320
Chargers Odds
SpreadTotalMoneyline
+7
-110
41.5
-112o / -108u
+265
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Chiefs vs. Chargers Spread: Chiefs -7.5
  • Chiefs vs. Chargers Over/Under: 41.5 points
  • Chiefs vs. Chargers Moneyline: Chiefs -350, Chargers +300
  • Chiefs vs. Chargers Pick, Prediction: Chargers to cover the 1H spread

Cleveland Browns at Las Vegas Raiders

Browns Logo
Sunday, Sep 29
4:25 p.m. ET
CBS
Raiders Logo
Browns Odds
SpreadTotalMoneyline
-2.5
-108
36.5
-108o / -112u
-140
Raiders Odds
SpreadTotalMoneyline
+2.5
-112
36.5
-108o / -112u
+120
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Browns vs. Raiders Spread: Browns -2.5
  • Browns vs. Raiders Over/Under: 37 points
  • Browns vs. Raiders Moneyline: Browns -140, Raiders +120
  • Browns vs. Raiders Pick, Prediction: Raiders to cover the spread

Sunday Night Football: Buffalo Bills at Baltimore Ravens

Bills Logo
Sunday, Sep 29
8:20 p.m. ET
NBC
Ravens Logo
Bills Odds
SpreadTotalMoneyline
+2.5
-105
46.5
-110o / -110u
+120
Ravens Odds
SpreadTotalMoneyline
-2.5
-115
46.5
-110o / -110u
-135
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Bills vs. Ravens Spread: Ravens -2.5
  • Bills vs. Ravens Over/Under: 46.5 points
  • Bills vs. Ravens Moneyline: Ravens -135, Bills +115
  • Bills vs. Ravens Pick, Prediction: Ravens to cover the spread

Monday Night Football Doubleheader: Tennessee Titans at Miami Dolphins

Titans Logo
Monday, Sep 30
7:30 p.m. ET
ESPN
Dolphins Logo
Titans Odds
SpreadTotalMoneyline
+2.5
-108
37
-110o / -110u
+115
Dolphins Odds
SpreadTotalMoneyline
-2.5
-112
37
-110o / -110u
-135
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Titans vs. Dolphins Spread: Dolphins -2.5
  • Titans vs. Dolphins Over/Under: 37 points
  • Titans vs. Dolphins Moneyline: Dolphins -135, Titans +115
  • Titans vs. Dolphins Pick, Prediction: Under the total

Monday Night Football Doubleheader: Seattle Seahawks at Detroit Lions

Seahawks Logo
Monday, Sep 30
8:15 p.m. ET
ABC
Lions Logo
Seahawks Odds
SpreadTotalMoneyline
+3.5
-108
46
-112o / -108u
+160
Lions Odds
SpreadTotalMoneyline
-3.5
-112
46
-112o / -108u
-185
Odds via DraftKings. Get up-to-the-minute NFL odds here.
DraftKings Logo
  • Seahawks vs. Lions Spread: Lions -3.5
  • Seahawks vs. Lions Over/Under: 46.5 points
  • Seahawks vs. Lions Moneyline: Lions -185, Seahawks +160
  • Seahawks vs. Lions Pick, Prediction: Under the Lions team total

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