NFL Predictions, Picks, Best Bets for Monday Night Football Games

NFL Predictions, Picks, Best Bets for Monday Night Football Games article feature image
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Action Network/Getty Images. Pictured: Trevor Lawrence (left), Josh Allen (left center), Joe Burrow (right center) and Jayden Daniels.

We close NFL Week 3 with not one, but two Monday Night Football games. We have you covered with NFL predictions across all markets.

First, the Jacksonville Jaguars (0-2) face the Buffalo Bills (2-0) on ESPN at 7:30 p.m. ET from Highmark Stadium in Orchard Park, N.Y. Then, the WashingtonCommanders (1-1) face the Cincinnati Bengals (0-2) on ABC at 8:15 p.m. ET from Paycor Stadium in Cincinnati. The Jaguars and Bengals are in desperate need of a win, as it is almost impossible to turn an 0-3 start into a playoff berth.

We have four quality quarterbacks on show tonight with Trevor Lawrence facing off against Josh Allen, while Jayden Daniels looks to impress against fellow LSU alum Joe Burrow.

NFL Predictions for Monday Night Football

Our experts have you covered for both games tonight.

We have a pick against the spread, on the over/under and a player prop for both games. We're betting the favorites on Monday night and betting a couple of overs with player props on Brian Thomas Jr. and Joe Burrow.


NFL Picks: Jaguars vs. Bills

Jaguars Logo
Monday, Sept. 23
7:30 p.m. ET
ESPN
Bills Logo
Jaguars Odds
SpreadTotalMoneyline
+5.5
-110
45.5
-110o / -110u
+200
Bills Odds
SpreadTotalMoneyline
-5.5
-110
45.5
-110o / -110u
-250
Odds via BetMGM. Get up-to-the-minute NFL odds here.
BetMGM Logo

Spread

By Billy Ward

One of my favorite things about the Josh Allen/Sean McDermott-era Bills is their willingness to put teams away. They don’t let up even when playing from ahead, continuing to stay aggressive throughout the game.

We saw this last week when they dominated the shorthanded Dolphins 31-10, and it’s been a hallmark of theirs for a few years now.

That makes it much easier to cover a spread like -5, a number that exists between the key numbers of 3 and 7. Teams that don’t keep putting up points could easily give up a “backdoor cover” to an opponent that scored a late touchdown down 10, for example.

Buffalo should hopefully close that door against a mediocre Jacksonville team that’s averaged just 15 points per game this season, and leave us with no doubt down the stretch.

Pick: Bills -5.5 (-110, bet365)

Total

By John LanFranca

With 12 plays of 20 or more yards, the Jaguars had produced the most explosive plays in the NFL entering Week 2. Trevor Lawrence is trying to get the ball down the field, which makes sense with new receivers Gabe Davis and rookie Brian Thomas Jr.

The Jaguars defense entered Week 2 ranked 18th in DVOA. It's one of the most aggressive defenses in recent memory, blitzing heavily and playing the most man coverage in the NFL through the first two weeks of the season.

I expect Josh Allen will take advantage of that aggressive Jaguars defense and burn them throughout the game. I'm expecting that will lead to a high-scoring game on Monday night.

Pick: Over 45.5 (-110, bet365)


Player Prop

By Matt Trebby

Brian Thomas Jr. has huge potential in the NFL. He’s already gone over this total in his first two NFL games and could have had more than the 94 yards he recorded in Week 1 against the Dolphins if Jalen Ramsey didn’t concede a long pass interference penalty instead of a 40-yard touchdown.

Our own Sean Koerner’s mean projection for Thomas’ receiving yards is 52. This could be a breakout performance for Thomas on Monday Night Football in front of a national audience.

I bet this at 40.5 on Saturday but would play it up to 44.5.

Pick: Brian Thomas Jr. Over 41.5 Receiving Yards (-115, BetMGM)



NFL Picks: Commanders vs. Jaguars

Commanders Logo
Monday, Sept. 23
8:15 p.m. ET
ABC
Bengals Logo
Commanders Odds
SpreadTotalMoneyline
+7.5
-110
47
-110o / -110u
+280
Bengals Odds
SpreadTotalMoneyline
-7.5
-110
47
-110o / -110u
-375
Odds via BetMGM. Get up-to-the-minute NFL odds here.
BetMGM Logo

Spread

By John LanFranca

Tee Higgins is poised to make his season debut, which means the Bengals will finally have their full complement of playmakers on offense. This is the perfect matchup for that since Washington's defense ranks 32nd — dead last — in success rate against the pass, points per drive allowed and third-down defense.

Jayden Daniels showed some great potential in Week 2 when the Commanders beat the Giants, but veteran Bengals defensive coordinator Lou Anarumo will be ready for him. His defense has allowed just one play of 20 or more yards this season, which means Daniels will have to be methodical and patient. That will be a hard ask on this stage.

Looking for a trend? Well, Joe Burrow has played in six NFL games after losing two in a row. The Bengals are 5-0-1 against the spread in those. The former No. 1 overall pick has also covered in 71% of games coming off a loss.

I'm expecting Cincinnati to be in full control and win by double digits at home in the final game of Week 3.

Pick: Bengals -7.5 (-115, bet365)

Total

By Stuckey

I think this total is a bit too low given some of the issues with both defenses.

I also expect Cincinnati to come out with a pass-heavy game plan to exploit its distinct advantages on the outside. And it really looked like Burrow started to get into rhythm last week in Kansas City.

On the other side, Washington should have sustained success on the ground and will, in all likelihood, have to eventually pick up the pace in a trailing game state.

Pick: Over 47.5 (-110, bet365)

Player Prop

By Nick Giffen

I'm using our NFL Luck Rankings to make this pick.

The Bengals are the more unlucky team entering this game, and they're favored. That means Cincinnati is more likely to cover and win the game, so it's more likely they run the ball more than usual.

The Bengals' Pass Rate Over Expectation (PROE) is 9.4% this year compared to 5.6% last year. What does that mean? The Bengals are throwing the ball more than expected, which makes sense since they trailed the Patriots for most of their Week 1 loss and played a tight one against the Chiefs in Week 2.

I'd rather bet on Burrow's completions here because of the matchup. The Commanders defense entered Week 2 ranked last in the NFL against short passes. I'm not convinced that Burrow's wrist is 100% and the difference between his short- and long-passing efficiency is massive.

I expect the Bengals to be more efficient with high-percentage passes on Monday night, which will help them keep the clock running and score points early before leaning on the run late.

Pick: Joe Burrow Under 34.5 Pass Attempts (-120, BetMGM)



About the Author
Action Network is a team of seasoned sports betting experts specializing in a broad range of sports, from the NFL and NBA to less mainstream options like cricket and darts. Their staff includes well-known analysts like Sean Koerner and Stuckey, recognized for their accurate predictions and deep sports knowledge. The team is dedicated to delivering expert analysis and daily best bets, ensuring bettors are well-informed across all major sports.

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