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NFL Week 2 Odds, Spreads, Totals for All 16 Games

NFL Week 2 Odds, Spreads, Totals for All 16 Games article feature image
Credit:

Kevin C. Cox/Getty Images. Pictured: Joe Burrow (left) and Patrick Mahomes.

Week 1 of the NFL season is just about in the books and Week 2 is on the horizon.

So, let’s get right to it with a look at the odds, spread and total for all 16 games on next week's slate.


NFL Week 2 Odds for All 16 Games

Bills vs. Dolphins Odds

Bills Logo
Thursday, Sept. 12
8:15 p.m. ET
Amazon Prime Video
Dolphins Logo
Bills Odds
SpreadTotalMoneyline
+1.5
-110
50.5
-110o / -110u
+100
Dolphins Odds
SpreadTotalMoneyline
-1.5
-110
50.5
-110o / -110u
-120
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

The Bills and Dolphins each rallied for a Week 1 victory. Josh Allen dominated with two touchdown passes and another two scores on the ground.

Meanwhile, Miami trailed the entire game against Jacksonville before winning on a Jason Sanders field goal as the clock struck zero.


Chargers vs. Panthers Odds

Chargers Logo
Sunday, Sept. 15
1 p.m. ET
CBS
Panthers Logo
Chargers Odds
SpreadTotalMoneyline
-5
-110
39.5
-110o / -110u
-240
Panthers Odds
SpreadTotalMoneyline
+5
-110
39.5
-110o / -110u
+195
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

The Chargers looked exactly like a Jim Harbaugh team typically looks, running roughshod over the Raiders with 176 yards on the ground while shutting Las Vegas out in the second-half.

They travel cross-country to take on the Panthers, who were dominated in a 47-10 loss to kickoff the season. Bryce Young’s struggles continued as he completed 13-of-30 passes for 161 yards and two interceptions.


Saints vs. Cowboys Odds

Saints Logo
Sunday, Sept. 15
1 p.m. ET
FOX
Cowboys Logo
Saints Odds
SpreadTotalMoneyline
+6.5
-105
45.5
-110o / -110u
+235
Cowboys Odds
SpreadTotalMoneyline
-6.5
-115
45.5
-110o / -110u
-290
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

Two teams who utterly dominated the opposition face off Sunday in Big D.

Dak Prescott and CeeDee Lamb showed why the Cowboys backed up the brink's trucks for them in a 33-17 win over the Browns while the Saints blew the Panthers out of the water, 47-10.


Raiders vs. Ravens Odds

Raiders Logo
Sunday, Sept. 15
1 p.m. ET
CBS
Ravens Logo
Raiders Odds
SpreadTotalMoneyline
+8.5
-110
42.5
-110o / -110u
+325
Ravens Odds
SpreadTotalMoneyline
-8.5
-110
42.5
-110o / -110u
-425
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

Baltimore lost in heartbreaking fashion when Isaiah Likely’s touchdown on the final play of the game was overturned as his toe was barely on the line.

The Ravens will look to get Derrick Henry rolling after he was stymied in Week 1 against a Raiders defense that gave up 176 rushing yards in a loss to the Chargers.


Buccaneers vs. Lions Odds

Buccaneers Logo
Sunday, Sept. 15
1 p.m. ET
FOX
Lions Logo
Buccaneers Odds
SpreadTotalMoneyline
+6.5
-110
49
-110o / -110u
+235
Lions Odds
SpreadTotalMoneyline
-6.5
-110
49
-110o / -110u
-290
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

The Lions kicked the season off with a hard-fought 26-20 overtime win over the Rams.

Detroit now hosts the Buccaneers, who won 37-20 over Washington behind four Baker Mayfield touchdown passes.


Jets vs. Titans Odds

Jets Logo
Sunday, Sept. 15
1 p.m. ET
CBS
Titans Logo
Jets Odds
SpreadTotalMoneyline
-4.5
-110
43.5
-110o / -110u
-220
Titans Odds
SpreadTotalMoneyline
+4.5
-110
43.5
-110o / -110u
+180
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

The Titans blew a 17-0 lead to the Bears in Week 1 and now host a Jets team who has aspirations for a deep Super Bowl run with Aaron Rodgers back in the fold.

Tennessee’s defense looked terrific despite the loss as it didn’t allow a touchdown all game. Meanwhile, this is the Jets second-straight road game to start the year as they begin the season in San Francisco.


Seahawks vs. Patriots Odds

Seahawks Logo
Sunday, Sept. 15
1 p.m. ET
FOX
Patriots Logo
Seahawks Odds
SpreadTotalMoneyline
-3
-115
39.5
-110o / -110u
-155
Patriots Odds
SpreadTotalMoneyline
+3
-105
39.5
-110o / -110u
+130
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

New England’s first game without Bill Belichick in over 25 years couldn’t have gone better as it beat the Bengals as eight-point underdogs. The Patriots defense frustrated Joe Burrow all day while Rhamondre Stevenson carried the ball 25 times for 120 yards and one touchdown.

For the Seahawks, Kenneth Walker was equally impressive with 20 carries for 103 yards and a TD.


Browns vs. Jaguars Odds

Browns Logo
Sunday, Sept. 15
1 p.m. ET
CBS
Jaguars Logo
Browns Odds
SpreadTotalMoneyline
+3
-105
42.5
-110o / -110u
+135
Jaguars Odds
SpreadTotalMoneyline
-3
-115
42.5
-110o / -110u
-160
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

Both teams fell in Week 1, but in differing fashions.

Cleveland wasn’t able to compete with the Cowboys as it was blown out at home, 33-17, while Jacksonville blew a 14-0 lead in a 20-17 loss to the Dolphins.


49ers vs. Vikings Odds

49ers Logo
Sunday, Sept. 15
1 p.m. ET
CBS
Vikings Logo
49ers Odds
SpreadTotalMoneyline
-5.5
-110
45
-110o / -110u
-245
Vikings Odds
SpreadTotalMoneyline
+5.5
-110
45
-110o / -110u
+200
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

The 49ers hit the road for the first time this season to take on their former backup quarterback.

Sam Darnold, who looked terrific in the Vikings’ 28-6 win over the Giants. Darnold was 19-for-24 for 208 yards, two touchdowns and one pick in his Vikings debut.

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Colts vs. Packers Odds

Colts Logo
Sunday, Sept. 15
1 p.m. ET
FOX
Packers Logo
Colts Odds
SpreadTotalMoneyline
-3
-120
41
-110o / -110u
-160
Packers Odds
SpreadTotalMoneyline
+3
+100
41
-110o / -110u
+135
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

Anthony Richardson looked as electric as any player in the NFL, showing off his cannon arm as well as his ability to carve a defense up with his legs. However, it wasn't enough as the Texans came out on top, 29-27.

Meanwhile, nobody knows who'll be under center for the Packers after Jordan Love suffered a knee injury late in Green Bay's season-opening loss to the Eagles. Malik Willis is the only quarterback on the roster while Sean Clifford is on the practice squad.


Giants vs. Commanders Odds

Giants Logo
Sunday, Sept. 15
1 p.m. ET
FOX
Commanders Logo
Giants Odds
SpreadTotalMoneyline
+2.5
-105
41
-110o / -110u
+120
Commanders Odds
SpreadTotalMoneyline
-2.5
-115
41
-110o / -110u
-140
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

The two NFC East rivals square off with the loser digging themselves an 0-2 hole. Daniel Jones struggled mightily in the Giants’ 28-6 loss to the Vikings, completing 22-of-42 passes for 186 yards, no touchdowns and a pair of interceptions.

Rookie Jayden Daniels flashed for Washington in its 37-20 loss to Tampa Bay, completing 17-of-24 passes for 184 yards along with 16 carries for 88 yards and two touchdowns.


Rams vs. Cardinals Odds

Rams Logo
Sunday, Sept. 15
4:05 p.m. ET
FOX
Cardinals Logo
Rams Odds
SpreadTotalMoneyline
-2.5
-110
50
-110o / -110u
-135
Cardinals Odds
SpreadTotalMoneyline
+2.5
-110
50
-110o / -110u
+115
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

The Rams' season opened in heartbreaking fashion as they fell to the Lions, 26-20, in overtime. They also lost star wideout Puka Nacua early in the game as he exited with a knee injury and did not return.

Los Angeles hits the road for the second-straight week for a divisonal showdown with the Cardinals, who gave the Bills all they could handle in a 34-28 loss in Buffalo.


Bengals vs. Chiefs Odds

Bengals Logo
Sunday, Sept. 15
4:25 p.m. ET
CBS
Chiefs Logo
Bengals Odds
SpreadTotalMoneyline
+6
-110
47
-110o / -110u
+210
Chiefs Odds
SpreadTotalMoneyline
-6
-110
47
-110o / -110u
-260
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

The Bengals suffered the biggest Week 1 upset in six years, falling to the Patriots as eight-point favorites in a 16-10 loss. They face a tough test this week against a Chiefs team who looked fantastic to open the season as they aim to become the first to ever win three Super Bowls in a row.

However, Joe Burrow's had success against the Chiefs as he's 3-1 against them in his career including the postseason.


Steelers vs. Broncos Odds

Steelers Logo
Sunday, Sept. 15
4:25 p.m. ET
CBS
Broncos Logo
Steelers Odds
SpreadTotalMoneyline
-2.5
-120
37.5
-110o / -110u
-150
Broncos Odds
SpreadTotalMoneyline
+2.5
+100
37.5
-110o / -110u
+125
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

Justin Fields started in Pittsburgh’s 18-10 upset over the Falcons after Russell Wilson suffered a calf injury earlier in the week. However, head coach Mike Tomlin told the media the team won’t know who’ll be under center in Week 2 until later in the week.

Their opponents in the Broncos showed heart in their 26-20 loss to the Seahawks. Rookie quarterback Bo Nix was 26-of-42 for 138 yards and two interceptions in his debut while adding five carries for 35 yards and a touchdown.


Bears vs. Texans Odds

Bears Logo
Sunday, Sept. 15
8:20 p.m. ET
NBC
Texans Logo
Bears Odds
SpreadTotalMoneyline
+6.5
-105
46
-110o / -110u
+235
Texans Odds
SpreadTotalMoneyline
-6.5
-115
46
-110o / -110u
-290
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

Chicago's defense bailed out Caleb Williams, who disappointed in his pro debut going 14-of-29 for 93 yards and no touchdowns for a 55.7 passer rating. Still, all that matters is the end result as the Bears head to Houston 1-0 after rallying for a 24-17 win.

In Houston, Joe Mixon proved to be a huge addition, carrying the ball 30 times for 159 yards in the Texans' win.


Falcons vs. Eagles Odds

Falcons Logo
Monday, Sept. 16
8:15 p.m. ET
ESPN
Eagles Logo
Falcons Odds
SpreadTotalMoneyline
+6
-110
48.5
-110o / -110u
+210
Eagles Odds
SpreadTotalMoneyline
-6
-110
48.5
-110o / -110u
-260
Odds via bet365. Get up-to-the-minute NFL odds here.
bet365 Logo

Kirk Cousins’ debut with the Falcons wasn’t what he envisioned, going 16-for-26 for 155 yards, one touchdown and two picks as Atlanta mustered only 10 points.

Meanwhile, Saquon Barkley had the exact opposite debut, totaling 132 yards and three touchdowns in the Eagles’ season-opening win over the Packers in Brazil.

About the Author
Ricky Henne writes for the Action Network's news team, covering all sports, events and breaking news. He also contributes to Action's NFL coverage. Ricky joined Action in 2022 with more than 20 years of experience covering professional sports. He wrote for the Los Angeles Chargers, New York Knicks and New York Rangers before entering the sports betting industry.

Follow Ricky Henne @rickyhenne on Twitter/X.

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