NFL Week 3: Odds, Spreads, Lines, Schedule for Every Game

NFL Week 3: Odds, Spreads, Lines, Schedule for Every Game article feature image
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Photo by Kevin Sabitus/Getty Images. Pictured: Jalen Hurts of the Philadelphia Eagles, as we look at the NFL Week 3 odds, spreads, lines, totals and schedule for every game.

Looking for all the latest on NFL Week 3: the odds, spreads, lines and schedule for every game?

Here's everything you need to know to prepare for the week ahead in the NFL, with NFL Week 3 odds, spreads and lines via FanDuel as of Monday night. You'll also find some of our early picks for Week 3 below.

For the latest NFL odds across the board, head over to our live updating NFL odds page — and make sure to check out our FanDuel promo code before you place your Week 3 bets.

NFL Week 3: Odds, Spreads, Lines, Schedule

Giants vs 49ers Odds

Giants Logo
Thursday, Sep 21
8:15pm ET
Amazon Prime Video
49ers Logo
Giants Odds
SpreadTotalMoneyline
+10.5
-105
44.5
-110o / -110u
+430
49ers Odds
SpreadTotalMoneyline
-10.5
-115
44.5
-110o / -110u
-590
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Brandon Anderson: Normally, I don't play a lot of high lines, but I think this one is going higher. We got blowout city coming in San Francisco. The last three times the Giants played a really good team? The Cowboys last week, 40-0. The Eagles in the playoffs, they lost by 31. The Eagles last regular season, they lost by 26.

So when the Giants play real teams, it has not gone well for them. They were dead last in DVOA against the run. This is the exact sort of team that the Niners just run it up on. I don't think Saquon Barkley is going to play in this one, and the Giants offensive line is a mess.

San Francisco has won 12 straight regular season games, and eight of the 12 wins are by 13 or more. I think that's about where this line is going to end up, and we're getting it at 10.5 now.

Pick: 49ers -10.5

🔥🔥 The Hot Read for Week 3 🔥🔥

We went 2-0 last week with significant CLV in both wins!

This week’s Hot Read is making a Thursday night stop and going back in on a team you already know I love.

Both lines already on the move!! 📈📈 pic.twitter.com/CRQiBQZKZd

— Brandon Anderson (@wheatonbrando) September 18, 2023

Chargers vs Vikings Odds

Chargers Logo
Sunday, Sep 24
1:00pm ET
FOX
Vikings Logo
Chargers Odds
SpreadTotalMoneyline
+1.5
-122
54.5
-105o / -115u
-106
Vikings Odds
SpreadTotalMoneyline
-1.5
+100
54.5
-105o / -115u
-110
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Bills vs Commanders Odds

Bills Logo
Sunday, Sep 24
1:00pm ET
CBS
Commanders Logo
Bills Odds
SpreadTotalMoneyline
-6.5
-110
44.5
-110o / -110u
-280
Commanders Odds
SpreadTotalMoneyline
+6.5
-110
44.5
-110o / -110u
+230
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Dylan Wilkerson: Perhaps because Raiders vs. Bills wasn't in primetime, the "Bills are back" news may be slow to circulate. Hopefully, that means we can get this number before it hits -7.

Even though the Commanders put together an amazing comeback in Week 2, it was with help from some timely penalties committed by the Broncos. The Bills were coming off of an embarrassing primetime loss against an Aaron Rodgers-less Jets team, but they cleaned up their act in Week 2 against the Raiders. Josh Allen didn't commit any turnovers, and neither did the entire Buffalo offense.

The Week 2 version of the Bills is the expectation we've become accustomed to with Allen at the helm. The Bills team from Week 1 was the exception.

Pick: Bills -6.5

Saints vs Packers Odds

Saints Logo
Sunday, Sep 24
1:00pm ET
FOX
Packers Logo
Saints Odds
SpreadTotalMoneyline
+1.5
-104
43.5
-110o / -110u
+112
Packers Odds
SpreadTotalMoneyline
-1.5
-118
43.5
-110o / -110u
-132
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Falcons vs Lions Odds

Falcons Logo
Sunday, Sep 24
1:00pm ET
FOX
Lions Logo
Falcons Odds
SpreadTotalMoneyline
+3.5
-110
45.5
-115o / -105u
+152
Lions Odds
SpreadTotalMoneyline
-3.5
-110
45.5
-115o / -105u
-180
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Titans vs Browns Odds

Titans Logo
Sunday, Sep 24
1:00pm ET
CBS
Browns Logo
Titans Odds
SpreadTotalMoneyline
+4
-115
41
-110o / -110u
+152
Browns Odds
SpreadTotalMoneyline
-4
-105
41
-110o / -110u
-180
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Texans vs Jaguars Odds

Texans Logo
Sunday, Sep 24
1:00pm ET
FOX
Jaguars Logo
Texans Odds
SpreadTotalMoneyline
+9.5
-115
44.5
-110o / -110u
+320
Jaguars Odds
SpreadTotalMoneyline
-9.5
-105
44.5
-110o / -110u
-405
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Patriots vs Jets Odds

Patriots Logo
Sunday, Sep 24
1:00pm ET
CBS
Jets Logo
Patriots Odds
SpreadTotalMoneyline
-3
-110
37.5
-110o / -110u
-154
Jets Odds
SpreadTotalMoneyline
+3
-110
37.5
-110o / -110u
+130
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Phone With the Action App Open
The must-have app for NFL bettors
The best NFL betting scoreboard
Free picks from proven pros
Live win probabilities for your bets

Broncos vs Dolphins Odds

Broncos Logo
Sunday, Sep 24
1:00pm ET
CBS
Dolphins Logo
Broncos Odds
SpreadTotalMoneyline
+6.5
-110
48.5
-110o / -110u
+240
Dolphins Odds
SpreadTotalMoneyline
-6.5
-110
48.5
-110o / -110u
-295
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Colts vs Ravens Odds

Colts Logo
Sunday, Sep 24
1:00pm ET
CBS
Ravens Logo
Colts Odds
SpreadTotalMoneyline
+8.5
-115
44.5
-110o / -110u
+300
Ravens Odds
SpreadTotalMoneyline
-8.5
-105
44.5
-110o / -110u
-375
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Panthers vs Seahawks Odds

Panthers Logo
Sunday, Sep 24
4:05pm ET
CBS
Seahawks Logo
Panthers Odds
SpreadTotalMoneyline
+4.5
-110
42.5
-110o / -110u
+180
Seahawks Odds
SpreadTotalMoneyline
-4.5
-110
42.5
-110o / -110u
-215
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Cowboys vs Cardinals Odds

Cowboys Logo
Sunday, Sep 24
4:25pm ET
FOX
Cardinals Logo
Cowboys Odds
SpreadTotalMoneyline
-12.5
-110
43
-110o / -110u
-720
Cardinals Odds
SpreadTotalMoneyline
+12.5
-110
43
-110o / -110u
+520
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Bears vs Chiefs Odds

Bears Logo
Sunday, Sep 24
4:25pm ET
FOX
Chiefs Logo
Bears Odds
SpreadTotalMoneyline
+13.5
-115
47.5
-110o / -110u
+540
Chiefs Odds
SpreadTotalMoneyline
-13.5
-105
47.5
-110o / -110u
-770
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Steelers vs Raiders Odds

Steelers Logo
Sunday, Sep 24
8:20pm ET
NBC
Raiders Logo
Steelers Odds
SpreadTotalMoneyline
-1.5
-102
45
-110o / -110u
-110
Raiders Odds
SpreadTotalMoneyline
+1.5
-120
45
-110o / -110u
-106
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Eagles vs Buccaneers Odds

Eagles Logo
Monday, Sep 25
7:15pm ET
ABC
Buccaneers Logo
Eagles Odds
SpreadTotalMoneyline
-5.5
-110
46
-110o / -110u
-230
Buccaneers Odds
SpreadTotalMoneyline
+5.5
-110
46
-110o / -110u
+190
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Cody Goggin: Without Shane Steichen on the Philadelphia sideline, the Eagles offense has not looked quite the same. Despite playing in two tight games, Jalen Hurts has decreased from 8.0 yards per attempt and 246.7 yards per game last year to 6.5 and 181.5 through two games this season.

Like Philly, Tampa Bay is 2-0 to start the year, but the Bucs have benefited from multiple turnovers by Minnesota and Chicago. There’s little doubt that the Bucs were the better team on the field in Week 2, but that’s not saying too much against the Bears.

With all of the talent the Eagles have on offense, this is hard to stomach, but I like this primetime game to go under its total — and I would take it down to 43.5.

Pick: Under 45 (Play to 43.5)

Rams vs Bengals Odds

Rams Logo
Monday, Sep 25
8:15pm ET
ESPN
Bengals Logo
Rams Odds
SpreadTotalMoneyline
+2.5
-118
43.5
-110o / -110u
+108
Bengals Odds
SpreadTotalMoneyline
-2.5
-104
43.5
-110o / -110u
-126
Odds via FanDuel. Get up-to-the-minute NFL odds here.
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Looking for more on the NFL odds for Week 3? Check out the latest NFL betting trends for every game courtesy of Vegas Insider at NFL Odds Week 3: Lines, Spreads, Betting Trends For Every Game.

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