White Sox vs. Red Sox Odds & Betting Predictions - April 21, 2025

White Sox at Red Sox

3:10 pm • NESN

Chicago White Sox

5-16

2 - 4

Boston Red Sox

12-11

pitcher		team	era	w-l
W.Buehler			5.23	2-1
J.Cannon			4.42	0-2

MatchupOpenSpreadTotalMoneyline
White Sox 5-16	N/A	N/A	N/A
Red Sox 12-11	N/A	N/A	N/A

Monday 3:10 p.m.

April 21, 2025

Fenway ParkBoston

CWS +2.5 (Live)-125

CWS +2.5-125

CWS o3.5 Team Total+105

0.5u

W.Buehler u1.5 BB+100

Under 9-105

0.95u

White Sox rank dead last in MLB in avg (.195), SLG (.306), OBP (.271). Just 2.89 runs/game on the road. Buehler induces weak contact (2.10 GB/FB), ideal at Fenway. White Sox 5th-worst in team wRC+ vs RHP. Boston’s bats cooled off – just .230 avg over last 10. Despite 6.2 runs/game at home, they’ve slowed vs weaker arms. Cannon flashed upside (4 K, 0 ER in 4 IP vs Athletics). Under has hit in 9 of last 12 matchups at Fenway between these teams. Pace, form, and splits all favor a lower score. Sox lack power, Buehler keeps ball down, Cannon’s better than full line shows. Wind light, no weather edge. Expect a grind.

J.Cannon o4.5 Ks+106

Under 0.5 (1st Inn)-110

1.1u

CWS +1.5+116

Under 9-110

BOS u5.5 Team Total-122

BOS -1.5-130

BOS -1.5-134

0.75u

Sticky sock

R.Devers o2.5 Hits + Runs + RBIs+110

Under 9-110

0.91u

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Apr 21, 2025 UTC

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No props found

MLB Public Betting

Red Sox are 4-1 in their last 5 games.
Red Sox are 3-2 in their last 5 games against the spread
Red Sox are 7-6 in their road games against the spread
The totals have gone OVER in 3 of Red Sox' last 5 games
The totals have gone OVER in 4 of Red Sox' 10 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Red Sox	11-12	4-6	7-6	7-9	4-3
White Sox	11-10	6-6	5-4	N/A	11-10

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Red Sox	9-13-1	4-5-1	5-8	5-10-1	4-3
White Sox	9-10-2	5-5-2	4-5	N/A	9-10-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Red Sox	12-11	6-4	6-7	9-7	3-4
White Sox	5-16	4-8	1-8	N/A	5-16

date	opponent	score	spread	over/under	moneyline
Apr 20th	CWS	L 4-8	-1.5 L	O 9.5	CWS -290
Apr 19th	CWS	W 4-3	-1.5 L	U 9	BOS -367
Apr 18th	CWS	W 10-3	-1.5 W	O 9.5	BOS -238
Apr 16th	@TB	W 1-0	+1.5 W	U 9	BOS +114
Apr 15th	@TB	W 7-4	+1.5 W	O 9	BOS +110

Lucas Giolito
P
Giolito is out with hamstring
Out
Connor Wong
C
Wong is out with finger
Out
Patrick Sandoval
P
Sandoval is out with elbow
Out
Kutter Crawford
P
Crawford is out with knee
Out
Brayan Bello
P
Bello is out with shoulder
Out
Masataka Yoshida
OF
Yoshida is out with shoulder
Out

Josh Rojas
IF
Rojas is out with toe
Out
Ky Bush
P
Bush is out with elbow
Out
Chase Meidroth
IF
Meidroth is day-to-day with thumb
Day-to-Day
Drew Thorpe
P
Thorpe is out with elbow
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RJ.Cannon, P	90	6	4	4
LT.Gilbert, P	23	1	3	0
RP.Murfee, P	17	1	1	0

HITTERS	H-AB	R	HR	RBI
1N.Maton, 1B	1-1	1	0	0
1B.Dalbec, PH	0-1	0	0	0
1B.Dalbec, 1B	0-1	0	0	0
2A.Benintendi, DH	2-3	1	1	1
3L.Robert, CF	0-4	0	0	0
4E.Quero, C	0-4	0	0	1
5L.Sosa, 2B	1-4	0	0	0
6M.Vargas, 3B	0-4	0	0	0
7B.Baldwin, LF	1-4	0	0	0
7B.Baldwin, SS	1-4	0	0	0
8M.Taylor, RF	0-3	0	0	0
8M.Thaiss, PH	0-1	0	0	0
9J.Amaya, SS	0-2	0	0	0
9J.Palacios, PH	0-1	0	0	0
9J.Palacios, LF	0-1	0	0	0

PITCHER	PC	IP	K	ER
RW.Buehler, P	100	7	9	1
LA.Chapman, P	16	1	1	1
RJ.Slaten, P	12	1	1	0

HITTERS	H-AB	R	HR	RBI
1J.Duran, CF	1-4	1	0	0
1J.Duran, LF	1-4	1	0	0
2R.Devers, DH	0-3	0	0	0
3A.Bregman, 3B	1-2	1	0	0
4T.Story, SS	3-4	1	0	1
5W.Abreu, RF	0-3	0	0	0
6K.Campbell, 2B	2-3	0	0	2
7T.Casas, 1B	0-4	0	0	0
8R.Refsnyder, LF	1-4	1	1	1
8C.Rafaela, CF	0-0	0	0	0
9C.Narvaez, C	0-4	0	0	0