As 10-point favorites the Clemson Tigers were stunned in Week 4 at North Carolina State, likely dashing Dabo Swinney and Company's playoff hopes.
Are they on upset alert again this Saturday versus Boston College?
The Tigers are laying 16 points at DraftKings against the Eagles with a total of 46.5 (click here for the latest college football odds).
According to Bet Labs, the visitors have a big historical edge in this ACC tilt.
Boston College vs. Clemson Betting Trends
Road underdogs getting seven or more points in a conference game with a closing total of 48 or below are 384-265-13 (59.2%) against the spread (ATS) since 2005.
This angle has yielded a 14.7% return on investment — $100 bettors playing every road underdog in this spot would be up a cool $9,758 lifetime.
The Eagles are a perfect 4-0 overall and 3-1 ATS this season, and fresh off a non-conference victory over Missouri.
Boston College's lone missed cover was Week 2 against UMass, a game in which the offense lost star quarterback Phil Jurkovec to a significant hand injury.
Clemson, meanwhile, has dropped all three games ATS versus FBS opponents this fall.
A club that had hopes of punching a bid to its seventh straight playoff appearance has barely impressed the voters, sitting No. 25 in the AP Poll.
Although Swinney has been on a tear in conference play (22-10 ATS) his Tigers are on the brink of dropping six straight covers dating back to last season.
