Michigan State vs. Ohio State Odds, Moneyline, Total
| Michigan State Odds | +20.5 (-110) |
| Ohio State Odds | -20.5 (-110) |
| Michigan State Moneyline | +700 |
| Ohio State Moneyline | -1125 |
| Over/Under | 68.5 |
| Time | 12 p.m. ET (Saturday) |
| TV | ABC |
Odds are via DraftKings as of Friday afternoon.
Michigan State will travel to Columbus to take on Ohio State in a game that will have wide-sweeping College Football Playoff and Big Ten implications.
The loser of this game will effectively be eliminated from College Football Playoff contention. The winner would put themselves in poll position to makecollege football's final four.
For instance, if Michigan State wins this game, all they would need to do is beat Penn State at home then Wisconsin or Iowa in the Big Ten Championship Game for a virtually guaranteed spot in the College Football Playoff.
For Ohio State, the road is murkier. A win here puts them in great position to make their fifth-ever College Football Playoff, but they would still need a win at Michigan next week at the Big House. That Wolverines team is incredibly solid. And that's just for a birth into the Big Ten Championship Game.
Then, a win over Wisconsin or Iowa would vault them into a virtually guaranteed spot in the final four.
This is all to say that this is a massive, massive game between two rivals that have had comparable seasons. And yet, the odds are heavily stacked toward Ohio State's favor.
Ohio State are favored by 20.5 points as of Friday afternoon.
That incredibly high number has left the public salivating all week. Michigan State +20.5 has the most total money out of all college football spreads this week, according to BetMGM.
The second-most money is with West Virginia at -3 hosting Texas, but it pales in comparison to the money on Michigan State to cover.
The third-highest handle is with the Oregon Ducks +3 at Utah.
