Notre Dame has been a mixed bag so far this season, and the Fighting Irish's football odds are once again in the spotlight as they prepare for a crucial matchup against undefeated Louisville this Saturday in Week 5 on Peacock.
Both teams are ranked — Louisville at 15 and Notre Dame at 16 — setting the stage for a marquee showdown in South Bend on Saturday. After bouncing back from an upset a few weeks ago, Notre Dame has secured back-to-back wins, positioning them well for this clash.
Our premium betting trends indicate an excellent betting strategy for games involving ranked teams, providing valuable insights for this pivotal matchup and how the outcome for Cardinals vs. Fighting Irish may pan out.
Notre Dame Fighting Irish Odds
| Louisville Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+6 -110 | 46.5 -110o / -110u | +185 |
| Notre Dame Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-6 -110 | 46.5 -110o / -110u | -225 |
The Fighting Irish are favored by -6 to -6.5 points, with the over/under set at 47.5.
Louisville has been impressive this season under head coach Jeff Brohm, going 3-0 against the spread.
Notre Dame Pick for Week 5
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According to our "Ranked Matchups" PRO System, betting on the