Notre Dame vs. Ohio State Odds
| Notre Dame Odds | +16 |
| Ohio State Odds | -16 |
| Over/Under | 59 |
| Date | Saturday, Sept. 3 |
| Time | 7:30 p.m. ET |
| Channel | ABC |
*Odds as of Saturday morning
Talk about a monster college football matchup right out of the gates.
Saturday's loaded college football Week 1 slate is already filled with in-state rivalry games and matchups between top-25 teams, but No. 5 Notre Dame vs. No. 2 Ohio State certainly takes the cake in terms of the most highly-anticipated game of the day.
While both teams are currently ranked among the AP's top five, the latest Notre Dame vs. Ohio State odds make this game even more interesting.
The Fighting Irish are massive 16-point underdogs against the Buckeyes on Saturday night, making Notre Dame the third-largest underdog since 2000 among teams ranked in the AP's top five.
I know, cool stat and all, but what does that mean for college football bettors?
Thanks for asking that very question, because the Action Network's college football picks and predictions provide a very clear answer.
Notre Dame vs. Ohio State Pick
There's no doubt that this is a huge spread for Ohio State to cover against a top-five opponent.
