Ohio State vs Penn State Leads Smartest Week 10 College Football Spread Picks

Ohio State vs Penn State Leads Smartest Week 10 College Football Spread Picks article feature image
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Head coach Ryan Day of the Ohio State Buckeyes waits to lead his team onto the field before the game against the Iowa Hawkeyes at Ohio Stadium on October 05, 2024 in Columbus, Ohio. (Photo by Jason Mowry/Getty Images)

Anticipation is high for Saturday's Week 10 college football matchups, particularly with three of PRO Projections' top picks that promise excitement — and potential upsets.

Three point spreads Saturday are way off when compared to Action PRO models, with two games showcasing the wrong teams being favored, according to our expert analysis.

Below, we delve into the lines for each of these games, explore what our proprietary betting data suggests and highlight which predictions you should consider locking in for maximum value on Saturday of Week 10.

We start with the site of College GameDay, and a betting line that can ultimately be exploited for the marquee matchup.


College Football Week 10 Predictions Against the Spread

Ohio State vs. Penn State Pick Saturday

First up is the showdown between No. 3 Penn State and No. 4 Ohio State. This is one of the biggest games of the year in college football.

According to the current betting lines, Ohio State is favored by three points.

However, diving deeper into our college football predictions, PRO Projections suggest