49ers vs Seahawks Picks, Odds, Spread: Thursday Night Football Predictions

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Zach Charbonnet #26 of the Seattle Seahawks. (Photo by Jane Gershovich/Getty Images)

PRO insights reveal a sneaky sharp way to bet 49ers vs. Seahawks picks for Thursday Night Football.

The Seattle Seahawks (3-2) are gearing up to host the San Francisco 49ers (2-3) in what promises to be an electrifying Thursday Night Football matchup at Lumen Field. The NFC West clash features star power on both sides.

The Seahawks boast quarterback Geno Smith and wide receiver DK Metcalf, while the 49ers look to wide receiver Deebo Samuel and linebacker Fred Warner to get back on track. Both teams are coming off losses, adding a layer of urgency to Thursday's NFL Week 6 contest. Currently, the 49ers are road favorites, with the over/under set at 49.5 points.

49ers vs. Seahawks Odds, Picks, Predictions

  • 49ers vs. Seahawks spread: 49ers -3.5
  • 49ers vs. Seahawks over/under: 49.5
  • 49ers vs. Seahawks moneyline: 49ers -190, Seahawks +155

Spread

The 49ers are favored by 3.5 points.

Over/Under

The over/under is set at 49.5 points, up from 47.5.

Moneyline

The moneyline is 49ers -190, Seahawks +155.

Point Spread

The point spread in PRO is drawing notable attention, with sharp action indicating a significant amount of professional money backing the 49ers.

Additionally, San Francisco is garnering 75% of the total money and 62% of the bets in the spread market, underscoring its position as the favored pick. However, our PRO Projections consider the spread with Seattle as only a +2.6 favorite, indicating a possible edge in Seattle's favor if the market overrates the 49ers.

Total

For the total, the under appears to be the savvy lean, with our PRO Projections suggesting the total should be closer to the open (47.5 points).

Odds to Win

On the moneyline, the PRO Projections suggest Seattle's odds should be closer to +134, presenting nuance against the market's current +157.

Our PRO Picks

Seahawks running back Zach Charbonnet helped cash a +650 prop a few weeks ago. One of Charbonnet's props for Thursday Night Football is the best way to bet the game.

Starting running back Kenneth Walker should see regular time. Charbonnet's rushing yards over/under is 12.5. That's a bit