The Cubs and Pirates were pushed out of the afternoon slot, putting all 30 MLB teams in action Friday evening.
And on the subject of the National League, it's where the public's putting its money ahead of the 15-game slate.
All five of the most-lopsided bets in our trackers Friday are in the NL, including Dodgers vs. Padres, Mets vs. Diamondbacks and Giants vs. Nationals.
5 Popular MLB Bets for Friday
*Odds and public betting trends data as of Friday afternoon. Find real-time MLB odds here.
1. Mets (-125) at Diamondbacks
9:40 p.m. ET
Bettors have no problem fading an Arizona offense that's dead-last in batting average (.176) through the first two weeks.
We've tracked a hefty 85% of the tickets on the Mets, the most of any moneyline (find public betting data here).
2. Giants (-130) at Nationals
7:05 p.m. ET
Another NL road favorite catching the public's attention is San Francisco behind left-hander Sam Long.
The Giants are the only other team Friday with more than eight of every 10 betting tickets on them, at 83%.
3. Cardinals (-125) at Reds
6:40 p.m. ET
Stop me if you've heard this before: Bettors like another road favorite, this time it's St. Louis.
The Cardinals are pulling in 79% of the wagers against the Reds, whose 2-11 record is the worst in baseball entering Friday.
4. Braves (-140) vs. Marlins
7:20 p.m. ET
Miami might be a trendy underdog this season, but not Friday.
The betting market likes Atlanta, which is getting 78% of the tickets as a short home favorite.
5. Dodgers (-150) at Padres
9:40 p.m. ET
It's the first meeting of the season between the Dodgers and Padres, who boast one of the best rivalries in the majors.
The tickets are rolling in on L.A. and southpaw Julio Urias. The Dodgers are pulling in 77% of the moneyline bets.