Aiyuk is back and healthy following a shoulder injury. He has six catches of 20-plus yards as well as two games with more than 120 receiving yards this season.
The Cowboys secondary tends to gample and plans a lot of man coverage, something Aiyuk has been the answer to for the Niners. With Trevon Diggs out and Deebo Samuel on the other side, Aiyuk should see a lot of 1-on-1 with Brock Purdy looking for him often.
This is the exact game where you want to bet on a Dak Prescott Anytime Touchdown. He has the rushing ability but hasn't had to use it much this season as his team has been up by three scores at halftime most weeks. But he ran a bit more when trailing against the Cardinals and saw a red-zone carry in that game.
Prescott threw two interceptions against this 49ers team in the playoffs last season and this may as well be a playoff game for the Cowboys.