Novak Djokovic opened as the favorite against Rafael Nadal prior to their French Open quarterfinal match, which is set to be played Tuesday.
Djokovic was listed at -225, while Nadal is a +175 underdog on Sunday afternoon, per PointsBet.
It's only the fifth time since 2010 that Nadal is an underdog at a clay-court event, but Djokovic accounts for four of those occurrences, including this match. Carlos Alcaraz was favored to beat Nadal at the Madrid Open earlier this year.
Djokovic has won each of the prior meetings with Nadal in which he was a favorite. Those came at the Monte Carlo Masters in 2015, the French Open in 2015 and at the Rome Masters in 2016.
Overall, Nadal holds a 19-8 head-to-head edge over Djokovic in clay-court matches. Djokovic holds an overall 30-28 lead in the rivalry.
The duo met twice on clay last year. Nadal beat Djokovic at the Rome Masters and Djokovic returned the favor at the French Open.
As it stands, Djokovic, listed at +160, is currently the odds-on favorite to win the French Open. Alcaraz is the second-favorite to take home the crown at +270 and Nadal is third at +300.
Listed at +600, Stefanos Tsitsipas is the only other player listed short of +1500 to win Roland Garros. However, he's also the only player on the bottom half of the draw from the names listed above.
Djokovic, Nadal and Alcaraz are all among the top half of the draw and if Alcaraz is able to win his quarterfinal, he'll square off with the winner of this Djokovic-Nadal match.
